Staphylococcus Aureus Induces IL-33, TSLP, and Muc5AC production by AERD Nasal Epithelium
نویسندگان
چکیده
منابع مشابه
IL-33 promotes Staphylococcus aureus-infected wound healing in mice.
Interleukin (IL)-33, a newly identified member of IL-1 family of cytokines, plays a crucial role in polarizing Th2-associated immune responses. Recently growing evidence indicates that IL-33 also represents an important mediator of mucosal healing and epithelial restoration. In this study, we investigated the effect of IL-33 on antimicrobial infection and wound healing using a Staphylococcus au...
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Approximately 20% of the population is persistently colonized by Staphylococcus aureus in the nares. Th17-like immune responses mediated by the interleukin-17 (IL-17) family of cytokines and neutrophils are becoming recognized as relevant host defense mechanisms for resolution of S. aureus mucocutaneous infections. Since antimicrobial peptides are regulated by the IL-17 cytokines, we sought to ...
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A persistent nasal carrier of Staphlylococcus aiureus tends to harbour the same phage type of organism for many months (Williams, 1946: Rountree and Barbour, 1951 : Gould and MeKillop, 1954). At the same time it has been shown that nurses in hospital possess a high carriage rate for penicillin-resistant Staph. aureus (Barber, Hayhoe, and Whitehead, 1949; Rountree and Thomson, 1952; Barber, Wils...
متن کاملIL-33 promotes gastrointestinal allergy in a TSLP-independent manner
Atopic dermatitis (AD) often precedes asthma and food allergy, indicating that epicutaneous sensitization to allergens may be important in the induction of allergic responses at other barrier surfaces. Thymic stromal lymphopoietin (TSLP) and interleukin (IL)-33 are two cytokines that may drive type 2 responses in the skin; both are potential targets in the treatment of allergic diseases. We tes...
متن کاملIL-33 induces IL-13 production by mouse mast cells independently of IgE-Fc RI signals
The IL-1-related molecules, IL-1 and IL-18, can promote Th2 cytokine production by IgE/antigen-Fc RI-stimulated mouse mast cells. Another IL-1-related molecule, IL-33, was identified recently as a ligand for T1/ST2. Although mouse mast cells constitutively express ST2, the effects of IL-33 on mast cell function are poorly understood. We found that IL-33, but not IL-1 or IL-18, induced IL-13 and...
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ژورنال
عنوان ژورنال: Journal of Allergy and Clinical Immunology
سال: 2019
ISSN: 0091-6749
DOI: 10.1016/j.jaci.2018.12.701